MBD3 and glioblastoma: Despite the divergence in downstream targets, Wnt–β-catenin and Wnt–Mbd3 branches both direct neuronal cell-fate determination in NPCs, giving the canonical Wnt pathway an eminent status as a target not only for driving neural stem cell reprogramming and directing neuronal lineage commitment, but also for advancing the control of cellular senescence to efficiently eradicate glioblastoma malignancy.