In this study, leveraging the extensive Caris Molecular Database encompassing tumor profiles analyzed at the Caris Life Sciences laboratory from 2008 to 2023, we identified cohorts of patients with BRCA and CRC (20,820 cases for CRC MMRd cohort; 20,879 cases for CRC MSI cohort; 15,173 cases for BRCA PD-L1 cohort). The gene discussed is CD274; the disease is colorectal carcinoma.