MDM2 and liposarcoma: In this regard, the observed increase in p53 protein in QN-302-treated U-2 OS cells is consistent with previous findings showing that the exposure of liposarcoma cells to QN-302 leads to a significant accumulation of p53 protein, likely due to the compound’s ability to interfere with MDM2 expression and affect the MDM2-p53 feedback loop [34].