CXCL8 and melanoma: This induction subsequently leads to the upregulation of IL-6 and IL-8 secretion, establishing an autocrine loop.112 Consistently, in cisplatin-induced senescent melanoma cells, the ERK1/2-RSK1 pathway is activated through IL-1α expression to promote the proliferation of nonsenescent cells and increase IL-8 secretion,46 thus synergistically amplifying the SASP effect.