This recruitment mechanism has been shown to effectively eradicate senescent liver cancer cells in murine models.189 The concurrent administration of CDK4/6 and MEK inhibitors in pancreatic ductal adenocarcinoma (PDAC) has been shown to elevate the levels of vascular endothelial growth factor (VEGF), leading to enhanced vascular density. The gene discussed is VEGFA; the disease is pancreatic ductal adenocarcinoma.