Studies have shown that inhibiting IL-1 signaling can disrupt immune surveillance, facilitating cancer cell evasion and survival in the presence of therapies.22 Conversely, elevating certain SASP components has been found to enhance the recruitment of immune cells, promoting the elimination of TISnt cancer cells.190 Therefore, it is crucial to carefully modulate SASP components within the TME by specifically targeting identified markers rather than arbitrarily reducing them. The gene discussed is IL1B; the disease is cancer.