Furthermore, in an immunocompetent mouse model of lung cancer, TGF-β induced a more profound senescent state under hypoxic conditions, and blocking TGF-β signaling in tumors eliminated naturally occurring senescent cells, reduced SASP levels, and diminished immunosuppressive immune cell infiltration, ultimately leading to antitumor effects.26 This evidence concerns the gene TGFB1 and lung carcinoma.