CD8A and cancer: Consequently, this creates a favorable microenvironment for the infiltration of CD8 + T cells into the TME and facilitates the diffusion of the chemotherapy drug gemcitabine, resulting in the effective elimination of cancer cells.190 Furthermore, the modified SASP resulting from autophagy inhibition exhibited heightened efficacy in inducing paracrine senescence in neighboring glioblastoma multiforme (GBM) cells.