Evidence supporting this hypothesis includes the observation of anergy in NK cells, weakening their anticancer function following intense stimulation by cancer therapy.132 Furthermore, lactate-driven M2 polarization of TAMs enhances pituitary adenoma invasiveness via SASP-mediated CCL17 secretion.133 Consequently, metabolic dysfunction in senescent immune cells may diminish their ability to compete for nutrients or energy with cancer cells, thereby fostering hypermetabolic reactions in cancer cells. Here, CCL17 is linked to cancer.