These cells facilitate the recruitment of non-senescent cancer cells by activating the CXCL12/CXCR4 signaling pathway, consequently promoting collective invasion in PTC.113 Apart from the intrinsic secretion of TISnt cancer cells, SASP factors originating from the surrounding TME predominantly exert deleterious effects on cancer cells, with a significant portion derived from senescent fibroblasts. This evidence concerns the gene CXCL12 and cancer.