This phenomenon is accompanied by elevated expression levels of LC3-I/II, PTEN-induced putative kinase 1 (PINK1), and lysosome-associated membrane protein 2 (LAMP2).120 Furthermore, ER stress represents another metabolic trigger of TIS.121 SASP-producing TISnt lymphoma cells demonstrate ER stress, the UPR, and increased ubiquitination. The gene discussed is LAMP2; the disease is lymphoma.