KCNIP3 and neoplasm: Ki-67 depletion has also been linked to reduced activity of the Dimerization partner, RB-like, E2F, and Multi-vulval class B (DREAM) complex, which depends on a functional p21 checkpoint.30–32 De Vicente et al. reported more p53-positive cells in OKC epithelium compared to dentigerous and radicular cysts, possibly reflecting overproduction or stabilization of wild-type p53 in response to increased proliferation.3 These findings suggest that OKCs may have impaired tumor suppressor function, contributing to their high proliferative potential—even in comparison to ameloblastomas.