For example, the transcriptomic classifiers IMX-BVN-2 and IMX-SEV-2, based on a 29-gene host expression signature, were able to differentiate between bacterial, viral and non-infectious illness (area under the curve (AUC) 0.80–0.90) and predict in-hospital mortality (AUC 0.84) among ED patients.47 48 A targeted proteomic study in paediatric ED patients used a three-protein panel (TRAIL, IP-10 and C-reactive protein) to distinguish bacterial from viral infections with high accuracy (AUC 0.90–0.92).49 This evidence concerns the gene CXCL10 and viral infectious disease.