The integration of diverse analytical approaches, including multiomics and microbiome profiling, allows for a comprehensive view of biological processes beyond conventional biomarkers like C-reactive protein and procalcitonin, whose predictive values for sepsis outcomes are limited.11 51 Another important strength is our ability to include severely ill patients unable to provide consent (eg, due to delirium), through consent from their legal representatives, ensuring representation of this vulnerable group. The gene discussed is CRP; the disease is Sepsis.