Subsequent incorporation of additional variables, such as FAQ [47], Alzheimer’s Disease Assessment Scale-Cognitive Subscale13-item version [48], Rey Auditory Verbal Learning Test [49], Mini-Mental State Examination [50], trail making test part B, time [51], brain volume features, APOE4 carriage, and brain age gap led to improved AUC scores, reaching 0.815, 0.798, 0.777, 0.731, 0.646, 0.672, 0.660, and 0.885, respectively. The gene discussed is APOE; the disease is early-onset autosomal dominant Alzheimer disease.