In the PPCCT participants with a history colorectal adenoma/serrated of polyp, who consumed diets with the Ca:Mg intake ratio of ≥2.6, optimizing the Ca:Mg intake ratio from over 2.6 to 2.3 through Mg supplementation did not change any of the following biomarkers: necroptosis (pMLKL and TRPM7), inflammation (COX-2), apoptosis (TUNEL and BAX), and cell proliferation (Ki67). The gene discussed is TRPM7; the disease is polyp.