To examine whether the absence of functional RBP1 affects acute retinal degeneration caused by exposure to bright light, Abca4−/−/Rdh8−/− and background-matched Abca4−/−/Rdh8−/−/Rbp1−/− mice were paired and exposed to 50,000 lux of LED light for 25 min. This evidence concerns the gene RDH8 and retinal degeneration.