<h4>Objectives</h4>The purpose of this study was to analyze the application of chitosan (CH)-<i>Aloe vera</i> (AV) gel on blood vessels, vascular endothelial growth factor (VEGF), and fibroblast growth factor (FGF) expression in traumatic ulcer healing.<h4>Materials and methods</h4>Chitosan powder with deacetylation degree of 93% dissolved in 2% acetic acid, neutralized with NaOH solution, and combined with AV gel. This evidence concerns the gene VEGFA and ulcer disease.