We assessed the cost-effectiveness of CCE in CRC screening.We simulated a Dutch cohort born between 1938 and 1957 for eight strategies: biennial FIT screening with cutoffs of 15 (FIT15) and 47 (FIT47) micrograms of hemoglobin per gram feces (μg Hb/g); biennial and triennial CCE screening; CCE after a FIT-negative result of 15-47 μg Hb/g (CCE triage); CCE after positive FIT using 15 and 47 μg Hb/g cutoffs; and 10-yearly colonoscopy screening. This evidence concerns the gene GSTM1 and colorectal carcinoma.