Retinal dopamine terminates normal eye growth and plays a pathogenic role in myopia.8,9 Dopamine reduced the levels of TNF-α and IL-6 and thereby suppressed inflammation.10,11 A pediatric clinical trial of a potent anti-inflammatory agent, crocetin,12 demonstrated a beneficial effect in slowing myopia progression.13 Despite clinical and experimental data on the association of myopia with inflammation, the origin of the inflammatory responses remains unidentified. This evidence concerns the gene IL6 and myopia.