In this study, by using the Tak1ΔM/ΔM mice as a unique CRC-resistant model, we demonstrated that the inhibition of chemokine expression by TH17 cytokines (IL-17A and IL-22) and subsequent infiltration of immune cells, particularly neutrophils and CD8+ cells, in colon epithelia are the key events for complete resistance to inflammation, tissue damage, and tumorigenesis. Here, IL17A is linked to colorectal carcinoma.