To further determine which TH17 cytokines are responsible for inhibiting chemokine expression and protect the Tak1ΔM/ΔM mice against colitis and CRC, we performed intracellular staining of key TH17 cytokines (IL-17A, IL-17F, IL-21, and IL-22) in CD4+ cells from intestinal LP. The gene discussed is IL21; the disease is colorectal carcinoma.