Although the roles of IL-17A and IL-22 in colon cancer are controversial and linked to both tumor-inhibiting and promoting effects, we have provided several lines of evidence that the cytokines protect epithelial barrier function by inhibiting the expression of an array of chemokines, particularly CCL5, CXCL5, and CXCL10. This evidence concerns the gene CCL5 and malignant colon neoplasm.