We found that the number of tissue-resident CD4+ cells in the colons of Tak1ΔM/ΔM mice (colitis resistant) was much higher than in wild-type (WT) and double KO (DKO) mice (Tak1ΔM/ΔM;ll1r1−/− and Tak1ΔM/ΔM;ll6−/−) (colitis sensitive) before DSS treatment and remained at a significantly higher level even after DSS treatment (Fig. 1, A and B). The gene discussed is CD4; the disease is colitis.