Furthermore, TIMER 2.0 (Tumor Immune Estimation Resource 2.0) analysis demonstrated that high C/EBPβ/STAT3 expression is linked to reduced CD8+ T cell infiltration in multiple aggressive cancers (e.g., lower-grade glioma, glioblastoma multiforme, kidney renal papillary cell carcinoma, and testicular germ cell tumors), providing further evidence that the C/EBPβ/STAT3 axis inhibits chemokine expression, thereby limiting cytotoxic T cell recruitment (Fig. 8B and fig. This evidence concerns the gene STAT3 and central nervous system cancer.