Compared with the non-CKD group, the CKD group exhibited significant differences in multiple variables, including lower albumin (ALB: 4.19 vs. 4.31, p < 0.001), higher serum creatinine (Scr: 98.41 vs. 74.99, p < 0.001), and elevated uric acid (UA: 5.96 vs. 5.31, p < 0.001). The gene discussed is ALB; the disease is chronic kidney disease.