Ufsp1 encodes for an enzyme (Ufsp1) involved in the UFMylation pathway, a type of Ubiquitin-like post-translational modification that has recently attracted significant attention because it regulates various biological processes, including ER membrane homeostasis, translation fidelity, DNA damage repair, response to viral infection, among others [17–22]. The gene discussed is UFSP1; the disease is viral infectious disease.