In the context of hematologic malignancies, particularly AML, emerging evidence from Wątek et al. underscores that hypogelsolinemia—a marked reduction in plasma gelsolin levels—is observed in AML patients, especially during the early stages of sepsis, suggesting that decreased GSN may contribute to the dysregulated apoptotic and inflammatory responses characteristic of this disease state [31]. The gene discussed is GSN; the disease is hematologic disorder.