DNMT3A and acute myeloid leukemia: Somatic mutation profiles were examined in 126 AML patients from the TCGA-LAML cohort, of whom 91 (72.22%) harbored at least one mutation in the top ten most frequently mutated genes (DNMT3A, FLT3, NPM1, TET2, CEBPA, IDH1, IDH2, RUNX1, WT1, and TP53) (Figs 6A and 6B).