During the EMT process, as OSCC cells lose cell polarity and cell adhesion molecules (such as E-cadherin), they acquire mesenchymal characteristics, such as a motile phenotype and the expression of mesenchymal markers (N-cadherin).Recent research has indicated that aberrant mitochondrial fission contributed to tumor progression [52].MTFR2, which is primarily involved in mitochondrial dynamics, particularly mitochondrial fission, can lead to imbalances in mitochondrial dynamics when abnormally expressed, thereby promoting cancer cell growth and proliferation. The gene discussed is MTFR2; the disease is neoplasm.