MTFR2 and cancer: During the EMT process, as OSCC cells lose cell polarity and cell adhesion molecules (such as E-cadherin), they acquire mesenchymal characteristics, such as a motile phenotype and the expression of mesenchymal markers (N-cadherin).Recent research has indicated that aberrant mitochondrial fission contributed to tumor progression [52].MTFR2, which is primarily involved in mitochondrial dynamics, particularly mitochondrial fission, can lead to imbalances in mitochondrial dynamics when abnormally expressed, thereby promoting cancer cell growth and proliferation.