MTFR2 and oral cavity squamous cell carcinoma: This study aims to investigate the core target of Astragaloside-Brucea javanica oil nanoemulsion (AS/BJO-NEs) against oral squamous cell carcinoma (OSCC) through network pharmacology, bioinformatics, and in vivo/in vitro experiments, elucidating its effects on epithelial-mesenchymal transition (EMT) mediated via MTFR2 and the underlying molecular mechanisms.