HCRT and hyperinsulinemic hypoglycemia, familial, 4: We propose herein that NT1 may induce a pattern of vasomotor activity not differing from that during sleep, but distinctly higher than in the healthy awake state through secondary effects on orexin deficiency on the regulation of noradrenergic activity, given that orexinergic activity is low in healthy sleep and low/absent in NT1 (27).