The binding of heterozygous alleles to FOXA1 and ERα is mirrored by allele-specific changes in chromatin accessibility and the recruitment of RNA polymerase II to a region believed to be an enhancer [31,32].However, even with the proposed potential pathways connecting FGFR2 rs2981578 to the risk of breast cancer, the precise mechanism underlying the development of breast cancer associated with this genetic variant remains unclear. Here, ESR1 is linked to breast cancer.