Inpancreatic β-cells, it is stored alongside insulin in acidicsecretory granules (∼pH 5.3) and cosecreted into the neutralextracellular space (∼pH 7.4). Itplays a pivotal role in glucose homeostasis by slowing gastric emptying,modulating gastric motility, and suppressing postprandial glucagonrelease. However, under pathological conditions,hIAPP aggregates into insoluble amyloid fibrils, which are prominentin the pancreatic islets of individuals with type 2 diabetes mellitus(T2DM). This aggregation is a major contributorto β-cell dysfunction and death, which exacerbates disease progression. This evidence concerns the gene INS and type 2 diabetes mellitus.