ATXN2L and hydrops fetalis: Both pregabalin and gabapentin bind specific subunits (α2δ-1 and α2δ-2) of P/Q-type and N-type neuronal voltage-gated calcium channels, decrease the release of neurotransmitters, and have antinociceptive effects.5 Cardiovascular adverse effects, such as peripheral edema6 and heart failure (HF),7,8 have been associated with both pregabalin and gabapentin potentially due to additional effects on α2δ subunits of L-type calcium channels located on arteries and ventricular cardiomyocytes.