In the current investigation, AlCl3-induced neurotoxicity in AD-like rats led to increased levels of Aβ1-42, p-tau, GSK-3β, and GFAP along with decreased levels of SIRT-1, BDNF, and CX3CL1 proteins, causing neuronal degeneration and amyloid deposition in the nerve cells of the hippocampus, which was investigated by the histopathological findings. This evidence concerns the gene GSK3B and Alzheimer disease.