Accordingly, our results suggest that CREM fusion variants likely are enriched among distally/acrally located AFH cases with a frequency of 33%, compared to unselected AFH cohorts in the literature, where CREB1 and ATF1 fusions are detected in > 90% of cases [11–13]. The gene discussed is CREM; the disease is histiocytoma, Angiomatoid fibrous.