Of those, BCAN and CNTN5 were significantly downregulated proteins in all three subtypes, where those significances associated with dementia have been shown in clinical studies [48, 49], with an average log2Fold-Change (FC) of −0.182, which represents a 16.9% reduction compared to an average log2FC of −0.156 for the remaining downregulated proteins. This evidence concerns the gene BCAN and dementia.