GPT and central nervous system cancer: In some ALT-cancer types (such as low-grade glioma or early-stage tumours), where current chemotherapeutic approaches are often curative and good prognosis is expected, focus is shifting to the risk of adverse events associated with genotoxic chemotherapies, including long-term morbidity, late-effects, and the emergence of secondary cancers—this being particularly relevant to ALT-positive cancers, as the majority occur in children and young people [26].