Specifically, in a study of pulmonary fungal infections, DCs from mice infected with an engineered strain of C. neoformans that produces IFN-γ (H99γ) exhibited robust pro-inflammatory responses, characterized by elevated levels of cytokines like NOS2, CXCL9, and IFN-γ, which correlated with controlled fungal burden and reduced disease severity. The gene discussed is IFNG; the disease is fungal lung infectious disease.