Moreover, since CD11c+ microglia have been implicated in other CNS diseases (e.g. Alzheimer disease Keren-Shaul et al., 2017, amyotrophic lateral sclerosis Xie et al., 2022, and multiple sclerosis Wlodarczyk et al., 2018), further investigations into the mechanisms driving CD11c+ microglia induction could provide insights into novel therapeutic strategies not only for neuropathic pain but also for other CNS diseases. Here, ITGAX is linked to Alzheimer disease.