The Drosophila nephrocyte has been well established to study the pathogenesis of APOL1-associated nephropathies (O'Toole et al., 2018; Gerstner et al., 2022; Rani and Gautam, 2018; Lee et al., 2023; Han and Olson, 2005). The gene discussed is APOL1; the disease is kidney disorder.