Comparison of negative and positive reinforcement learning in DMD mouse models shows that negative reinforcement is not impacted by loss of dystrophin, whereas positive reinforcement, such as a food reward, can lead to improved performance in mdx/bl10 compared to WT mice (Vaillend et al., 1998; Lewon et al., 2017; Dickson and Mittleman, 2019). Here, DMD is linked to Duchenne muscular dystrophy.