Based on the analysis of the ACS study group, the clinical model included in the multivariate analysis showed that high Gal-3 levels were associated with the composite of all-cause mortality, non-fatal MI, and stroke (adjusted HR 2.178, 95% CI 1.200–3.951, p = 0.010), and high Gal-3 had a significant association in multivariate analysis including clinical model plus hs-CRP (HR 1.988, 95% CI 1.063–3.720, and p = 0.032). Here, LGALS3 is linked to Stroke.