In the lower group (NRG-1 < 122.5 pg/ml), MACCEs were reported in 30 patients, which included 7 individuals hospitalized due to HF, 20 patients with ACS, 1 patient with severe arrhythmia, 1 patient with stroke, and 1 patient who experienced sudden cardiac death. The gene discussed is NRG1; the disease is cardiac arrhythmia.