Furthermore, we observed that none of the variables used to subgroup patients (including age, smoking history, family history of early-onset cardiovascular disease, and prevalence of hypertension, diabetes mellitus or hyperuricemia) had a significant effect on the relationship between the NRG-1 level and MACCEs, which highlights the applicability of our findings to the majority of individuals. The gene discussed is NRG1; the disease is diabetes mellitus.