NRG1 and atherosclerosis: After adjustment for other covariables (age, sex, BMI, blood pressure, heart rate, smoking status, family history of early-onset CVD, hypertension, dyslipidemia, diabetes, hyperuricemia, use of lipid-lowering drugs, glycosylated hemoglobin, creatinine, eGFR, uric acid, glucose, TG, TCHO, HDL-c, LDL-c, LVEF, MCP-1, MPO and VCAM-1), a binary analysis revealed that among the set of influencing variables for ASCVD, NRG-1 remained an independent protective factor (OR = 0.855, 95% CI = 0.814–0.899, P < 0.001; Table 2).