SPEF2 and nasopharyngeal carcinoma: A second homolog of the gene, SPEF2, is also present in several species, suggesting that these genes are part of a novel gene family.14 Interestingly, mRNA encoding SPEF2 has been found in multiple myeloma18 and nasopharyngeal carcinoma.19 SPEF2, which plays an important role in the differentiation and function of ciliated cells, has also been included as a member of the CTA family (www.cta.lncc.br/index.php).