IGHE and asthma: As Michelle Jamieson (2017) has similarly argued in her discussion of scientific and clinical evidence of the role of immunoglobulin E (IgE) in the causes of asthma, the changeability and indeterminacy of disease trajectories requires a relational understanding of causality, that includes living conditions and circumstances (on indeterminacy in disease causality see Hinchliffe, 2001; Schrader, 2010).