To obtain the diagnostic model for PPD, we used 10 key genes (TPP2, AKR1B1, CD59, PARK7, PLXNB2, HLA-B, FAH, NDST1, SCARB1, and HNRNPA2B1) to calculate the relative contribution weights of these genes to the risk of diseases. Here, TPP2 is linked to progressive pseudorheumatoid arthropathy of childhood.