In this study, we assessed serum ATGL levels in healthy controls, Type 2 DM (T2DM) patients, and DKD patients with both microalbuminuria (L-DKD) and macroalbuminuria (H-DKD), aiming to explore the relationship between serum ATGL and renal function in T2DM. Here, PNPLA2 is linked to diabetic kidney disease.