To date, few studies have explored the potential interactions between Tet3 and key neural stem cell markers such as Ascl1, Lin28, and Nestin. It has been demonstrated that Tet 3 works in a self-regulatory axis with Let7 and Lin28 to maintain stemness in pancreatic cancer cells (Liu et al., 2020). This evidence concerns the gene ASCL1 and familial pancreatic carcinoma.