ACE and hydrops fetalis: These subgroups also demonstrated varying responses to commonly used HF medications, including diuretics, angiotensin-converting enzyme (ACE) inhibitors, beta-adrenergic blocker drugs, and nitrates, suggesting the potential benefits of personalized therapeutic approaches [30]. The Zisis DMP-Plus has a total of 34% reduction in 30-day readmissions (AI group: 22/202 vs. control: 54/202), and the Altus Care App has 70% daily furosemide reduction + 90% Kansas City Cardiomyopathy Questionnaire (KCCQ) improvement (validated by 100% six-minute walk (SMW) test gains).