Among these altered genes, CST1 could serve as a reliable diagnostic factor (AUC = 0.904), the finding being in line with previous reports on esophageal squamous cell carcinoma,27 endometrial cancer,52 and early-stage non-small cell lung cancer.53 In addition, our analysis revealed that CST2 expression was associated with most clinicopathological parameters, indicating its possible role in tumor progression. The gene discussed is CST2; the disease is esophageal squamous cell carcinoma.