Workers in industries such as rubber, dye, leather, and chemical manufacturing are at an elevated risk due to prolonged exposure to carcinogenic compounds, particularly aromatic amines.4 Conditions that cause chronic bladder inflammation, such as recurrent urinary tract infections or long-term catheter use, also increase the risk of developing bladder cancer.5 In addition, family history and specific genetic mutations (e.g., mutations in TP53 and FGFR3) are associated with increased bladder cancer risk.6 This evidence concerns the gene TP53 and urinary bladder carcinoma.