METTL3 and breast cancer: For example, studies have shown that melittin selectively downregulates METTL3 expression in BC cells, thereby modulating m6A levels.13 On the other hand, hypoxic conditions can regulate m6A levels by suppressing METTL16 expression.17 Demethylation is carried out by FTO and ALKBH5, which recognize and remove m6A modifications on RNA, thereby modulating RNA stability and translational efficiency.24