Upregulating FTO to modulate m6A demethylation levels, particularly for oncogenes such as MALAT1 and NOTCH1, can help increase cancer cell sensitivity to chemotherapy.80 Furthermore, research indicated that METTL3 enhances BC cell resistance to melittin by regulating the expression of miR-146a-5p.13 This evidence concerns the gene METTL3 and cancer.