miR-146a-5p’s suppression of NUMB activates the oncogenic NOTCH2 signaling pathway, revealing METTL3’s critical role as an oncogenic factor in BC and enhancing BC cells’ proliferative and invasive abilities.13 In addition, METTL3 and YTHDF2 facilitate the degradation of rat sarcoma virus-related (RRAS) mRNA through m6A modification, destabilizing RRAS. Here, NUMB is linked to breast cancer.