The depletion of TRMT6/TRMT61A slows the average migration speed of 5,637 cells, potentially impacting cell migration ability.78 BC cells with high m5C expression, particularly muscle-invasive BC cells, exhibit higher methylation levels and increased invasiveness.57 Ying et al. 73 demonstrated that the loss of METTL1 significantly suppresses BC cell migration, invasion, and distant metastasis. Here, METTL1 is linked to breast cancer.