NFKB1 and ischemic stroke: In vivo animal experiments have also confirmed that the synchronized release of both W and L of Danshen demonstrates superior therapeutic effects for ischemic stroke compared to W alone, L alone, or a simple mixture of W and L. Subsequent mechanistic studies have shown that W and L exert their combined therapeutic effect by synergistically inhibiting the NF-κB and TNFα pathways in neurons, thereby improving cellular inflammation levels.