The glycosylation of apolipoprotein B, extensive N-linked glycosylation of fatty acid translocase, and the interaction between carbohydrate response element-binding protein and O-GlcNAc transferase have all been closely associated with metabolic dysregulation and inflammatory responses in the progression of NAFLD (Ihara et al., 1998; Guinez et al., 2011). This evidence concerns the gene MLXIPL and metabolic dysfunction-associated steatotic liver disease.