Specifically, a statistically significant upregulation of ADAM10 mRNA was observed in the ALL group treated with a combination of vincristine (VCR) and methotrexate (MTX) (P=0.0001,∗∗∗∗) and in the group treated with doxorubicin (DOXO) (P=0.001,∗∗∗). The gene discussed is ADAM10; the disease is acute lymphoblastic leukemia.