ADAM10 and acute lymphoblastic leukemia: Our analysis of ADAM10 expression, detailed in Figures 1a, 1b, and 3, revealed a statistically significant upregulation at both the mRNA and protein levels in Acute Lymphoblastic Leukemia (ALL) cases following treatment with a combination of vincristine (VCR) and methotrexate (MTX), as well as with doxorubicin (DOXO).