This section, illustrated by Figure 4 for mRNA and protein levels Figure 5, aimed to investigate the regulation of CD58 expression in both treated acute lymphoblastic leukemia (ALL) and untreated chronic lymphocytic leukemia (CLL) cases, specifically examining the impact of vincristine, methotrexate, and doxorubicin chemotherapy on ALL samples. This evidence concerns the gene CD58 and acute lymphoblastic leukemia.