This is further supported by studies showing that the ADAM10 inhibitor GI254023X can inhibit Jurkat cell proliferation, induce apoptosis, and modulate NOTCH1 expression (down-regulating Cleaved Notch1 and up-regulating total Notch1), providing strong evidence for ADAM10's involvement in T-ALL pathogenesis (20). The gene discussed is NOTCH1; the disease is acute lymphoblastic leukemia.