To elucidate how GPX4 protein interactions are involved in COAD progression, we used the STRING database to identify 10 hub genes co-expressed with GPX4, including GSR, GRSF1, HPGDS, HSPA5, PRDX6, GSTO2, GSTP1, GSTO1, CHAC1, and GSS (Fig. 2A). Here, CHAC1 is linked to colon adenocarcinoma.