STAT3 and hepatocellular carcinoma: In hepatocellular carcinoma (HCC), VPS37A downregulation activates Signal Transducer and Activator of Transcription 3 (STAT3)-driven metastasis [28], while its deficiency impairs autophagy-lysosomal degradation, compromising mitochondrial quality control and exacerbating genomic instability in early tumorigenesis [29].