Cross-validation using GEO cohorts (GSE39582, p = 7.7e−05; GSE71187, p = 3.9e−04; GSE87211, p = 9.6e−07) (Fig. 1B−D), paired transcriptomes (GSE44076, tumor vs. normal, p = 3.7e−07) (Fig. 1E) and CPTAC proteomics (p = 7.05e−05) (Fig. 1F) consistently demonstrated VPS37A depletion at both mRNA and protein levels. Here, VPS37A is linked to neoplasm.