To test the above hypothesis, several angiogenesis-related cytokines were analyzed for their mRNA levels in CRC cells with sh-USP13 or Flag-USP13 expression (Fig. 4A,B) and the mRNA levels of VEGFA, VEGFB, VEGFC, VEGFD, PDGFB, PDGFC, THBS1, WNT7B, PGF, bFGF, MMP2, and CXCL9 were quantified. Here, THBS1 is linked to colorectal carcinoma.