The mRNA expression levels of VEGFA, VEGFB, VEGFD, PDGFB, PDGFC, THBS1, PGF, and CXCL9 were significantly upregulated in CRC cells with USP13 knockdown, while WNT7B and MMP2 mRNA expression levels were significantly downregulated (Fig. 4A). This evidence concerns the gene MMP2 and colorectal carcinoma.