Through studies on diffuse large B-cell lymphoma, it was found that in ibrutinib-resistant cells, early growth response factor 1 (EGR1) increased its binding to the PDP1 promoter and transcription start site region while downregulation of EGR1 led to a reduction in PDP1 mRNA and protein expression levels, which in turn increased PDH phosphorylation levels. This evidence concerns the gene EGR1 and lymphoma.