In studies of acute myeloid leukemia, PDP1 is essential for FLT3-ITD cells under hypoxia, as it allows for a rapid transition to OXPHOS when oxygen becomes available; this transition is linked to significant upregulation of PDP1 upon inhibition of the FLT3-ITD signaling pathway, which results in a distinct OXPHOS metabolic profile with provides cytotoxic protection. Here, PDP1 is linked to acute myeloid leukemia.