Studies on FLT3-ITD metabolism in acute myeloid leukemia found that PDP1 gene knockdown reduced cellular respiration, thereby weakening the proliferation of FLT3-ITD-positive cells, even under hypoxic conditions, FLT3-ITD-positive cells continued to rely on PDP1 and exhibited rapid, PDP1-dependent recovery of respiratory capacity during reoxygenation. The gene discussed is PDP1; the disease is acute myeloid leukemia.