Further research on brain metastasis in breast cancer has confirmed that overexpressing STAT3 significantly restores the proliferative ability of triple-negative breast cancer (TNBC), STAT3 is closely related to the autophagy process and participates in the occurrence of brain metastasis in TNBC by regulating the expression of autophagy-related genes [118]. This evidence concerns the gene STAT3 and breast carcinoma.