Astaxanthin, a ketocarotenoid antioxidant, was demonstrated to ameliorate cell proliferation, apoptosis avoidance, invasion, and angiogenesis by abrogating the PI3K/Akt signaling axis in SCC131 and SCC4 OSCC cells, and in a hamster model of oral cancer [128]. Here, PIK3CA is linked to lip and oral cavity carcinoma.