Moreover, since COVID‐19 associated ischemic strokes are more severe with worse functional outcomes and higher mortality than non‐COVID‐19 ischemic strokes [31], we studied, by using an in vitro model of brain ischemia, whether S1 could increase the severity of brain injury by modulating a specific HDACs isoform and RIPK1. Here, RIPK1 is linked to ischemic stroke.