Since we demonstrated that HDACs, CREB, and RIPK1 could be connected in several neurotoxic pathways [19, 20, 21, 28, 29], and are individually related to COVID‐19 physiopathology [25, 27, 30], herein, we investigated the possible relationship between Spike S1‐neurotoxicity and HDACs, CREB, and RIPK1 expression in SH‐SY5Y cells transiently transfected with the S1 vector or exposed to the S1 protein. The gene discussed is RIPK1; the disease is COVID-19.