CREB1 and COVID-19: Since we demonstrated that HDACs, CREB, and RIPK1 could be connected in several neurotoxic pathways [19, 20, 21, 28, 29], and are individually related to COVID‐19 physiopathology [25, 27, 30], herein, we investigated the possible relationship between Spike S1‐neurotoxicity and HDACs, CREB, and RIPK1 expression in SH‐SY5Y cells transiently transfected with the S1 vector or exposed to the S1 protein.