TP53 and osteosarcoma: Indeed, it has been demonstrated that Spike: (1) promotes IL‐6 trans‐signaling by activation of the angiotensin II receptor in A543 epithelial cells [47]; (2) inhibits p53 activation in U2OS osteosarcoma cell line [48]; and (3) interacts with MAO‐B, impairing mitochondrial bioenergetics and inducing oxidative stress through mitophagy in SH‐SY5Y cells [49].