Most genes within the module were upregulated in the IMQ condition, including Il23a, Il17a, Il22, Il1b, Ifng, and S100a8/9, whereas Mki67 exhibited higher expression in control samples (Figure 3D), possibly reflecting reduced proliferative drive or differing kinetics of proliferation in the IMQ model compared to human psoriasis. The gene discussed is S100A8; the disease is psoriasis.