Following initial clustering of cell types (Figure 1A; Supplementary Figure S1A), we calculated a psoriasis module score based on key psoriasis-associated genes (S100A7A, S100A8, S100A9, IL17A, IL1B, IL22, IFNG, KRT6A, KRT16, MKI67, and IL23A), which revealed a strong increase in lesional psoriatic skin and a moderate increase in non-lesional skin compared to healthy controls (Figures 1B–D), confirming accuracy of the disease-state and providing a reliable platform for further analysis. The gene discussed is IL22; the disease is psoriasis.