For instance, patients with osteoarthritis often exhibit elevated baseline levels of systemic inflammatory markers such as C-reactive protein (CRP) [11] and lactate [12]; and a locally disturbed balance of proinflammatory and anti-inflammatory cytokines, such as interleukin-6 (IL-6), IL-1β, α-tumor necrosis factor (TNF-α), and IL-10 [13]. This evidence concerns the gene IL6 and osteoarthritis.